?-Galactosidase A is an acidic hydrolase that catalyzes the removal of terminal ?-glucosidase groups from glycoproteins and glycolipids.{62981,62980} It is ubiquitously expressed and functions as a homodimer with each monomer containing an N-terminal a(?/?)8 domain and a C-terminal anti-parallel ? domain.{62978,62981} Mutations in GLA, the gene encoding ?-galactosidase A, induce lysosomal ?-glucosidase A deficiencies, which cause Fabry disease, an X-linked lysosomal storage disorder characterized by hypohidrosis and heat intolerance, as well as cardiac, CNS, and vascular dysfunction.{62982,62980} ?-Galactosidase A activity is decreased in dried blood spots from patients with Parkinson's disease but not harboring the Parkinson's disease-associated mutations in LRRK2, LRRK2G2019S, or in glucocerebrosidase.{62979} Cayman’s ?-Galactosidase A Rabbit Monoclonal Antibody (Clone 001) can be used for ELISA and immunoprecipitation (IP) applications.