TNF Ligand Superfamily Member 12 (TWEAK), FLAG Tag, human recombinant, (rHuTNFSF12-HEK-FLAG)

Binds to FN14 and possibly also to TNRFSF12/APO3. Weak inducer of apoptosis in some cell types. Mediates NF-kappa-B activation. Promotes angiogenesis and the proliferation of endothelial cells. Also involved in induction of inflammatory cytokines. (www.uniprot.org) Human recombinant TWEAK is manufactured with N-terminal fusion of 13 amino acid FLAG Tag. The TNFSF12 flag -tagged fusion protein is an 18.7kDa protein containing 169 amino acid residues and 13 additional amino acid residues - flag tag. TNFSF12 is a cytokine that is part of the TNF ligand family. TNFSF12 is a ligand for the FN14/TWEAKR receptor. TNFSF12 has overlapping signaling functions with TNF, but displays a much wider tissue distribution. TNFSF12 induces apoptosis through multiple pathways of cell death in a cell type-specific manner. TNFSF12 promotes proliferation and migration of endothelial cells, and therefore acts as a regulator of angiogenesis. TNFSF12 is expressed in adult heart, pancreas, skeletal muscle, small intestine, spleen and peripheral blood lymphocytes. TWEAK h induces NFkB and chemokine secretion. TNFSF12 promotes proliferation and migration of endothelial cells.