Aminoguanidine (hydrochloride)
Aminoguanidine is equipotent to L-NMMA and L-NNA as an inhibitor of iNOS.{1856,1859} The IC50 values for inhibition of mouse iNOS and rat nNOS are 5.4 and 160 µM, respectively.{1859} Aminoguanidine also inhibits induction of iNOS protein expression by endotoxin in rat macrophages.{3447}
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