L-NNA
L-NNA is a competitive inhibitor of nitric oxide synthase (NOS) with selectivity for the neuronal and endothelial isoforms of the enzyme. Although L-NAME is much more soluble than L-NNA in aqueous systems, a hydrolysis step is required to “activate” L-NAME, thus adding complexity to an in vivo experiment.{5433} L-NNA inhibits nNOS, eNOS, and iNOS with Ki values of 15 nM (bovine), 39 nM (human), and 4.4 µM (mouse), respectively.{1857,5648}
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L-NNA
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