EDN ELISA Kit

Upon activation, eosinophils secrete several cationic proteins including major basic protein (MBP), eosinophil cationic protein (ECP), eosinophil peroxidase (EPO) and eosinophil-derived neurotoxin (EDN). EDN, also called eosinophil protein X (EPX), is a glycosylated single-chain protein with a molecular weight 18-21 kDa and is a member of the ribonuclease superfamily along with ECP11)-13). Although EDN has high sequence homology to ECP, EDN has 100-fold greater ribonuclease activity than ECP and neurotoxicity but not cytotoxicity9,10. Eosinophil activation has been found to play an important role in inflammatory processes in allergic diseases. EDN can be a marker of eosinophil activation and degranulation. The “EDN ELISA Kit” is a useful reagent for specifically measuring Human EDN with high sensitivity by ELISA.