DMOG
The pro-angiogenic factor HIF-1? is targeted for destruction in normoxic environments by the hydroxylation of a specific proline residue, P564, by the oxygen-sensing enzyme HIF-1? prolyl hydroxylase (HIF-PH).{8840} DMOG is a cell permeable, competitive inhibitor of HIF-PH. It acts to stabilize HIF-1? expression at normal oxygen tensions in cultured cells, at concentrations between 0.1 and 1 mM.{8840} DMOG is therefore expected to act as a pro-angiogenic compound, acting via the HIF-1? system.{9790,8799}
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