anti-HSP60 mouse monoclonal, HSP60-1, purified

HSP60-1 reacts with Heat Shock Protein 60 or HSPD1, found in mitochondria. A wide variety of environmental and pathophysiological stressful conditions trigger the synthesis of a family of proteins known as heat shock proteins (HSP’s), more appropriately called as Stress Response Proteins (SRP’s). HSP60 is a potential antigen in a number of autoimmune diseases. In human arthritis and in experimentally induced arthritis in animals, disease development coincides with the development of immune reactivity directed against not only bacterial HSP60, but also against its mammalian. Positive control: HeLa or HepG2 cells. Synovial biopsies from patients with juvenile chronic arthritis. Synovial lining layer is strongly positive for hsp60. Carcinomas.