anti-CD55 mouse monoclonal, 143-30, purified

143-30 Reacts with CD55 or DAF (Decay Accelerating Factor). All leucocytes as well as human erythrocytes, fibroblasts, platelets, endothelial cells and neuroectodermal cells are positive for DAF, a glycosylphosphatidylinositol anchored (GPI-anchored) member of the membrane bound complement regulatory proteins that inhibit autologous complement cascade activation. CD55 also serves as receptor for CD97 and for echovirus and coxsackie B virus. DAF is deficient in both granulocytes and monocytes in patients with paroxysmal nocturnal haemoglobinuria. 143-30 Has been clustered in Vienna at the IVth International Workshop on human leucocyte differentiation antigens. Positive control: Jurkat, HUT-78, K562, YT, U937, MG63, and human lymphocytes, human lymph nodes and tonsils.