anti-TIP47 / PP17, mouse monoclonal, clone 49.19

TIP47 (tail-interacting protein of 47 kD; also named Perilipin 3, PLIN3) is involved in lipid droplet maturation (see e.g. Bulankina 2003 and 2009). The protein has been localized in milk fat globule membranes of human and bovine origin. It has been described also as a placental protein. Increased amounts of TIP47/PLIN3 are secreted into circulation of cervix carcinoma patients. After radical surgery PLIN3 serum levels are decreased (cf. Than et al. 1999). TIP47/PLIN3 shows about 40% sequence homology to adipophilin (PLIN2). The antibody, however, is specific for TIP47/PLIN3 and does not cross-react with adipophilin (PLIN2) and perilipin (PLIN1) or other proteins of the PLIN/PAT family.Reactivity on cultured cell lines: PLC, A431, HT29, HeLa, SV-80; human pre-adipocytes Bulankina, A. V et al. TIP47 functions in the biogenesis of lipid droplets. J. Cell Biol. 185, 641–55 (2009). Bulankina, A. V. TIP47 is recruited to lipid droplets and important for the organelle biogenesis and function. Computing (2003). Than, N. G., Sumegi, B., Than, G. N., Kispal, G. & Bohn, H. Cloning and sequencing of human oncodevelopmental soluble placental tissue protein 17 (PP17): Homology with adipophilin and the mouse adipose, differentiation-related protein. Tumor Biol. 20, 184–192 (1999).