Mab to Lamin type A and C
The monoclonal antibody decorates the lamina, i.e. the nucleoplasmic layer coating the nuclear envelope. Mutations in lamin A have been shown to cause Hutchinson-Gilford progeria syndrome in human and mouse and other laminopathies (for review see Burke & Stewart, 2002). Polypeptides reacting: Lamin isotypes A and C (Mr 60 - 75 kD); meiotic lamin C2 Reactivity in cultured cell lines: RV-SMC (rat vascular smooth muscle cells) Antigen recognized in species: Xenopus laevis LA human LA, C bovine LA, C mouse LA, C rat LA, C trout LA zebrafish LA
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Mab to Lamin type A and C
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