anti-Desmocollin 3, mouse monoclonal, clone Dsc3-U114

Mab localizes Dsc3 present in all living epidermal layers in glandular duct cells in basal matrix cells and outer root sheath of hair follicles basal and suprabasal cell layers of stratified epithelia (e.g. vagina, tongue, esophagus), basal layer of bladder urothelium and complex epithelium of trachea thymic reticulum cells All simple epithelia are negative. Intercalated disks of myocardium are negative. Polypeptide reacting: 109 kD and 100 kD polypeptides (desmocollin 3 splice isoforms at pI 5.2) from human epidermal desmosomes.Reactivity on cultured cell lines: Most cultured cell lines derived from stratified squamous epithelia or squamous cell carcinomas are positive (e.g. A-431, HaCaT).