anti-TKTL1, mouse monoclonal, clone VU-7H2

Expression studies on transketolase-like-1 show that the protein is found in aggressive tumors. The detection of TKTL1 is furthermore correlated with poor patient prognosis and metastasis. Transketolase dependent reactions regulate the non-oxidative part of the pentose-phosphate-pathway (PPP) in glucose metabolism. This pathway generates NADPH and pentose phosphates. The latter are important for nucleic acid metabolism. Beside the ubiquitous transketolase (TKT) other transketolase-like proteins exist. Transketolase-like 1 (TKTL1) is a protein with a 38 amino acid deletion when compared to TKT. TKTL1 expression has been shown in tumors of different entities. Inhibition of TKTL1 expression by RNA interference results in reduced growth of tumor cells, while overexpression of TKTL1 promotes cell proliferation. Recent publications suggest an important role of TKTL1 in the metabolism of tumor cells. In colorectal tumors nuclear as well as cytoplasmic localization has been described. Reactivity on cultured cell lines: THP-1.