Vascular Endothelial Growth Factor-121, human recombinant (rHuVEGF-121)
Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin. NRP1/Neuropilin-1 binds isoforms VEGF-165 and VEGF-145. Isoform VEGF165B binds to KDR but does not activate downstream signaling pathways, does not activate angiogenesis and inhibits tumor growth. (www.uniprot.org) Produced in E.coli. Homodimer, polypeptide chain containing 2 x 121 amino acids.
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Vascular Endothelial Growth Factor-121, human recombinant (rHuVEGF-121)
52625.2
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