Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation Acts on B-cells, T-cells, hepatocytes, hematopoeitic progenitor cells and cells of the CNS. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. (www.uniprot.org) Produced in E.coli. Single, non-glycosylated polypeptide chain containing 184 amino acids. The ED50 as determined by the dose-dependant stimulation of murine 7TD1 cells is < 0.1 ng/ml.