5-OxoETE Receptor Blocking Peptide

To be used in conjunction with Cayman’s 5-OxoETE Receptor Polyclonal Antibody (Item No. 100025) to block protein-antibody complex formation during immunochemical analysis of 5-OxoETE. The 5-OxoETE receptor recognizes eicosatetraenoic acids and polyunsaturated fatty acids including 5-Oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid (5-OxoETE), which is the most potent ligand.{11953} 5-OxoETE is a potent stimulator of chemotaxis for eosinophils and neutrophils that mediates its action via a putative G-protein coupled receptor (GPCR).{10476,11003} The receptor couples to Gi/o to inhibit cyclic AMP production and to mobilize intracellular calcium.{10476,11003} Northern blot analysis reveals that the receptor is highly expressed on eosinophils and neutrophils, suggesting a key role in the inflammatory response.{11003} In addition, the protein can also be detected in tissues such as kidney and liver.{10476,11003}