12(S)-HpEPE
12(S)-HpEPE is an active metabolite of the ?-3 fatty acid eicosapentaenoic acid (EPA; Item Nos. 90110 | 90110.1 | 21908).{68558} It is formed from EPA by 12-lipoxygenase (12-LO). 12(S)-HpEPE (0.3 and 1 µM) inhibits IL-1?-induced increases in the levels of COX-2 in human pulmonary microvascular endothelial cells (HPMECs).{68559}
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