Perfluorotridecanoic Acid

Perfluorotridecanoic acid (PFTrDA) is a perfluoroalkyl substance (PFAS). Embryo larval exposure of PFTrDA induces yolk sac edema and increases mRNA expression of thyroid hormone synthesis genes, including tsh?, in zebrafish when used at concentrations of 0.1 and 0.3 mg/L, respectively.{64777} PFTrDA (10 mg/kg) decreases serum testosterone and luteinizing hormone levels, testis palmitic acid (Item No. 10006627), linoleic acid (Item Nos. 90150 | 90150.1 | 21909), and oleic acid (Item Nos. 90260 | 24659) levels, and the number of Leydig cells in rats in late puberty.{64779} Maternal plasma levels of PFTrDA during gestation are positively associated with the development of eczema in female, but not male, infants, and liver levels of PFTrDA are higher in cancerous human livers compared with non-cancerous human livers.{55648,64778} It has been found in marine mammals.{65487}