Lamotrigine-d3
Lamotrigine-d3 is intended for use as an internal standard for the quantification of lamotrigine (Item No. 15428) by GC- or LC-MS. Lamotrigine is an anticonvulsant.{25270} It inhibits voltage-gated sodium channels (Nav) in HEK293 cells expressing recombinant human Nav1.2, Nav1.5, or Nav1.8 (IC50s = 10, 62, and 96 ?M, respectively), as well as high voltage-activated calcium currents in isolated rat cortical neurons (IC50 = 12.3 µM), an effect that can be reversed by the N-type calcium channel blocker ?-conotoxin GVIA (Item No. 24114) and P-type calcium channel blocker ?-agatoxin IVA (Item No. 21605).{25270,64617} Lamotrigine protects against seizures induced by maximal electroshock (MES) in mice and rats (ED50s = 10.1 and 7.4 µmol/kg, respectively).{64618} It also decreases mechanical allodynia in a rat model of neuropathic pain induced by spinal nerve ligation (ED50 = 47 µmol/kg).{25270} Formulations containing lamotrigine have been used in the treatment of epilepsy and bipolar disorder.
Do you have any questions about this product?
Order your product by email
Productname
Lamotrigine-d3
37196-1
By filling out this form, you are placing an order by e-mail. You will receive an order confirmation within one working day. The order cannot be modified after receipt of the order confirmation.
Request a sample
Productname
Lamotrigine-d3
37196-1
By filling out this form, you request a sample. You will receive an order confirmation within one working day. The order cannot be modified after receipt of the order confirmation.
Are you looking for specific products, alternatives or documentation?
