ITGAL/CD11a Chimeric Monoclonal Antibody
CD11a, also known as integrin ?L (ITGAL), is a protein subunit of the heterodimeric leukocyte integrin ?L?2.{59670} It is composed of an extracellular domain that contains an I-domain and a metal-binding domain, which are important for binding, a transmembrane region, and a short cytoplasmic tail.{65394} CD11a is expressed ubiquitously on the surface of leukocytes as a component of ?L?2, which binds to intracellular adhesion molecule 1-5 (ICAM-1-5), junctional adhesion molecule A (JAM-A), and endothelial cell-specific molecule 1 (ESM-1) to facilitate T cell adhesion and migration during extravasation into the lymph nodes and tissue.{65395} SNPs in ITGAL are associated with a reduced susceptibility to Beh?et’s disease, a systemic inflammatory disease.{65396} Cayman’s ITGAL/CD11a Chimeric Monoclonal Antibody was recombinantly generated based on the sequence of the original humanized anti-CD11a antibody hu1124.{66193} It can be used for flow cytometry (FC).
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ITGAL/CD11a Chimeric Monoclonal Antibody
37155-200
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ITGAL/CD11a Chimeric Monoclonal Antibody
37155-200
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