YQ-128
YQ-128 is an inhibitor of the NOD-like receptor protein 3 (NLRP3) inflammasome (IC50 = 0.3 µM).{62631} It inhibits LPS- and ATP-induced IL-1? release from isolated mouse peritoneal macrophages (IC50 = 1.59 µM). YQ-128 (10 mg/kg) inhibits LPS-induced IL-1? production in wild-type but not Nlrp3-/- mice.
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