Product description

CD73, also known as ecto-5'-nucleotidase, is a membrane-bound ectoenzyme that catalyzes the hydrolysis of AMP to adenosine, a mediator of purinergic signaling pathways.{63385,63386} It exists as a homodimer where each monomer is composed of a catalytic N-terminal domain, a C-terminal substrate-binding domain, and a glycosylphosphatidylinositol (GPI) anchor that is attached to the cell membrane.{63385} CD73 is ubiquitously expressed, and a soluble form of CD73 (sCD73) can be produced by proteolytic cleavage of its GPI anchor.{63385} It is upregulated by hypoxia and a variety of pro-inflammatory mediators, including TGF-?, IFN, TNF-?, IL-1?, and prostaglandin E2 (PGE2).{63387} The enzymatic activity of CD73 is coupled to CD39, the enzyme that produces AMP from ATP, a danger signal produced from injured or dying cells.{63386} CD73 converts AMP to adenosine, a ligand for adenosine receptors, which regulate various physiological responses, including inflammatory pathways.{63386,63387} It has other immunoregulatory functions, including acting as a T cell co-stimulatory molecule, inhibiting macrophage-mediated inflammation, and facilitating lymphocyte tethering to the endothelium.{63386} CD73 has additional roles in the maintenance of tissue barrier function, cardioprotection during ischemia-reperfusion injury, and cancer, where it promotes metastasis, angiogenesis, and immune evasion.{63388} Increased tumor CD73 expression is associated with poor overall survival in patients with breast or ovarian cancer.{63389} Cayman's Ecto-5'-nucleotidase/CD73 Rabbit Monoclonal Antibody can be used for immunohistochemistry (IHC) and Western blot (WB) applications.

Specifications
Applications
IHC, WB
Host
Rabbit
Clone
RM431
Isotype
IgG
Supplier
Cayman Chemical
Shipping & storage
Shipping condition
Dry Ice
Storage temperature
-20°C

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Ecto-5’-nucleotidase/CD73 Rabbit Monoclonal Antibody

35613-100

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Ecto-5’-nucleotidase/CD73 Rabbit Monoclonal Antibody

35613-100

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