SC-43
SC-43 is an activator of Src homology region 2 domain-containing phosphatase 1 (SHP-1).{60794} It activates SHP-1 phosphatase activity in a cell-free assay and inhibits IL-6-induced phosphorylation of STAT3 in PLC/PRF/5 hepatocellular carcinoma cells when used at a concentration of 10 µM. SC-43 inhibits the proliferation of PLC/PRF/5 cells (IC50 = 0.5 µM). It decreases disease severity and improves survival in a mouse model of carbon tetrachloride-induced liver fibrosis when administered at doses of 10 and 20 mg/kg.{60795}
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