?-Actin is a cytoskeletal protein with roles in cell division, migration, and homeostasis that is encoded by ACTB in humans.{52776,52777} It is ubiquitously expressed, localized to the cytosol, and conserved from birds to mammals. ?-Actin is enriched at the leading edge of migrating cells and Actb-/- mouse embryonic fibroblasts (MEFs) exhibit decreased migration velocity, increased apoptosis, and decreased proliferation.{52776} Actb knockout is early embryonic lethal in mice, indicating that ?-actin is essential for embryonic development. ACTBR183W and ACTBE346K gain-of-function mutations have been found in patients with deafness, developmental mutations, and juvenile-onset dystonia and neutrophil dysfunction, respectively.{52778} Cayman's ?-Actin (N-Term) Rabbit Monoclonal Antibody - Biotinylated can be used for chromatin immunoprecipitation (ChIP), immunocytochemistry (ICC), immunohistochemistry (IHC), immunoprecipitation (IP), and Western blot (WB) applications.
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B-Actin (N-Term) Rabbit Monoclonal Antibody - Biotinylated
32377-50
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Productname
B-Actin (N-Term) Rabbit Monoclonal Antibody - Biotinylated
32377-50
By filling out this form, you request a sample. You will receive an order confirmation within one working day. The order cannot be modified after receipt of the order confirmation.
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