Fc?RII/CD23 (C-Term) Rabbit Monoclonal Antibody

CD23, also known as Fc?RII, is a type II transmembrane glycoprotein and C-type lectin encoded by FCER2 in humans.{60240} It is composed of a short N-terminal cytoplasmic domain, a membrane-spanning region, a stalk region, and a large C-terminal globular domain. CD23 is expressed in T and B cells, polymorphonuclear leukocytes, bone marrow stromal cells, follicular dendritic cells, and intestinal epithelial cells. Alternative splicing of FCER2 pre-mRNA produces two isoforms, CD23a and CD23b, which differ by seven amino acids in the N-terminal cytoplasmic domain and exhibit distinct functions, as well as different uptake and recycling patterns. CD23 is the low-affinity receptor for IgE and has roles in the growth and development of normal and leukemic B cells, antimicrobial immunity, and monocyte activation.{60240,60241} It can also be released from cell surfaces by the metalloprotease ADAM10 as various soluble CD23 proteins (sCD23), all of which bind IgE and have cytokine-like activity.{60240} Serum levels of CD23 are increased in patients with chronic lymphocytic leukemia (CLL) or hairy cell leukemia.{60242} Cayman’s Fc?RII/CD23 (C-Term) Rabbit Monoclonal Antibody can be used for immunohistochemistry (IHC) and Western blot (WB) applications.