CD38 Rabbit Monoclonal Antibody

CD38, also known as ADP-ribosyl cyclase 1, is a single-chain type II transmembrane glycoprotein with enzymatic activity and cell surface receptor functions that has roles in calcium signaling and immunomodulation.{59815,59816,59817} It is composed of a C-terminal catalytic domain, which can be orientated towards the extracellular or intracellular environment, a transmembrane segment, and a short N-terminal cytoplasmic tail, which interacts with the tyrosine kinase Lck.{59815,59818} CD38 expression is induced by cytokine, interferon, or endotoxin stimulation in a variety of immune cells, including T cells, B cells, granulocytes, and natural killer (NK) cells, as well as malignant plasma cells, and predominantly localizes to lipid rafts.{59815,59817,59816} It is also found in the nucleus and mitochondrial membrane, as well as in the cytoplasm.{59815} CD38 regulates calcium signaling by catalyzing the formation of the intracellular calcium mobilizing messengers cyclic ADP-ribose and nicotinic acid adenine dinucleotide phosphate (NAADP).{59819} It is a receptor for CD31, an adhesion molecule expressed by endothelial cells, and associates with a variety of signaling complexes, such as CD3/T cell receptor and CD19/CD21/B cell receptor complexes.{59817,59815} CD38 protein expression is increased on plasma cells isolated from patients with multiple myeloma.{59820} Cayman's CD38 Rabbit Monoclonal Antibody can be used for immunohistochemistry (IHC) and Western blot (WB) applications.