CD33 (C-Term) Rabbit Monoclonal Antibody

CD33 is a transmembrane receptor and member of the sialic acid-binding immunoglobulin-type (Ig-type) lectin (SIGLEC) family.{54696} It is composed of N-terminal extracellular Ig-like variable (IgV) and Ig-like constant 2 (IgC2) domains, as well as intracellular immunoreceptor tyrosine-based inhibitory motif (ITIM) and ITIM-like (ITL) domains. CD33 has two isoforms formed via alternative splicing, a full-length form and CD33m, which lacks the IgV-like domain.{54697} The full-length form is expressed on myeloid progenitor cells and in microglia while CD33m is found in myeloid cells and lymphocytes.{54696,54697} CD33 is an inhibitory receptor activated by binding of sialic acid-containing molecules, such as glycolipids and glycoproteins, to the IgV domain, which stimulates phosphorylation of tyrosine in the ITIM domain, leading to recruitment of Src homology 2 domain-containing phosphatases (SHPs) and internalization of the CD33-ligand complex.{54698} Signaling downstream of CD33 inhibits phagocytosis and cytokine release from immune cells, as well as regulates immune cell growth and survival. CD33 protein is found on patient-derived acute myeloid leukemia (AML) progenitor cells but not non-cancerous stem cells.{54699} A SNP in CD33 is associated with, and considered a risk factor for, Alzheimer’s disease.{54696} Cayman’s CD33 (C-Term) Rabbit Monoclonal Antibody can be used for immunohistochemistry (IHC) and Western blot (WB) applications.