Cytokeratin 10 (C-Term) Rabbit Monoclonal Antibody
Cytokeratin 10 (CK-10) is a type I acidic epithelial intermediate filament protein.{52912} It is composed of a central rod containing four ?-helical domains, which are important for self-assembly, and non-helical head and tail domains at the N- and C-termini, respectively.{15723} CK-10 expression is induced upon keratinocyte differentiation, increasing during keratinocyte migration from the basal layer to the suprabasal layer of the epidermis.{52912} It dimerizes with the type II epithelial intermediate filament protein CK-1 via heptad repeats in the central rod domain to form a network of filament bundles throughout the cytoplasm.{58060} Increased tumor CK10 expression has been found in patients with hepatocellular carcinoma (HCC) and is associated with poor prognosis.{60204} CK10 mutations have been found in patients with epidermolysis bullosa simplex (EBS), a disorder characterized by skin blistering.{58060} Cayman's Cytokeratin 10 (C-Term) Rabbit Monoclonal Antibody can be used for immunohistochemistry (IHC) and Western blot (WB) applications.
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Cytokeratin 10 (C-Term) Rabbit Monoclonal Antibody
32313-100
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Cytokeratin 10 (C-Term) Rabbit Monoclonal Antibody
32313-100
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