Integrin B3/CD61 Rabbit Monoclonal Antibody

Integrins are cell adhesion receptors that mediate the attachment of cells to the extracellular matrix (ECM) and facilitate cell-cell interactions.{59572} The integrin family contains 18 ? subunits and eight ? subunits that form 24 different heterodimers grouped into familial subgroups based on subunit composition and/or their ligand binding properties. Integrin ?3, also known as CD61, is an integrin subunit that associates with ?IIB or ?v integrin subunits, forming ?IIB?3 and ?v?3 integrin heterodimers, respectively, which function as receptors for a variety of ECM proteins, including fibrinogen, fibronectin, and collagen and mediate outside-in and inside-out signaling cascades.{58263,58264,58265} Integrin ?3 is composed of a ligand-binding extracellular domain, a single transmembrane segment, and a short cytoplasmic tail.{58264} It is expressed by platelets, megakaryocytes, and endothelial cells, as well as monocytes and macrophages. Mutations in ITGB3 have been found in patients with Glanzmann thrombasthenia, a hemorrhagic disease characterized by defects in platelet function, and ITGB3 SNPs are associated with increased risk of myocardial infarction.{58263} Cayman's Integrin ?3/CD61 Rabbit Monoclonal Antibody can be used for immunohistochemistry (IHC) and Western blot (WB) applications.