Cytokeratin 5/Cytokeratin 6 (C-Term) Rabbit Monoclonal Antibody

Cytokeratin 5 (CK5) and CK6 are type II intermediate filament proteins.{15723,52960} They are each composed of a central rod containing four ?-helical domains, which are important for self-assembly, and non-helical head and tail domains at the N- and C-termini, respectively. CK5 is expressed in basal keratinocytes in the epidermis and is an integral component of the epithelial cell cytoskeleton.{58059} It dimerizes with the type I epithelial intermediate filament protein CK14 via heptad repeats in the central rod domain to form a network of filament bundles throughout the cytoplasm.{58060,15723} CK6 expression is restricted to ectoderm-derived epithelial appendages, such as hair follicles, nails, and teeth, but is induced at sites of wound injury and persists until barrier function is restored and the wound is closed.{52960} CK5 and CK6 are associated with poor prognosis in patients with high-grade serous ovarian carcinoma or triple-negative breast cancers.{52961,52962} Cayman’s Cytokeratin 5/Cytokeratin 6 (C-Term) Rabbit Monoclonal Antibody can be used for immunohistochemistry (IHC) and Western blot (WB) applications.