CR2/CD21 (C-Term) Rabbit Monoclonal Antibody

Complement receptor 2 (CR2), also known as CD21, is a type I transmembrane glycoprotein with a role in the complement system.{57408} It is composed of an extracellular domain that contains 15 or 16 short consensus repeats involved in stabilizing the triple-loop domain conformation, a transmembrane domain, and a short cytoplasmic domain containing one PKC and one tyrosine kinase phosphorylation site. CR2 is primarily expressed on mature B cells and follicular dendritic cells (FDCs) but is also expressed on the pharyngeal and cervical epithelium, thymocytes, and a subset of peripheral T cells.{57408,57409} It forms a complex with CD19, TAPA-1, and Leu-19 on the surface of B cells, where it acts as a ligand-fixing subunit that binds surface-fixed cleavage fragments of complement protein C3 on antigen presenting cells to amplify antigen-induced B cell activation and antibody production.{57408} CR2 is also a receptor for Epstein Barr Virus. B cell levels of CR2 are decreased in patients with systemic lupus erythematosus (SLE).{57407} Cayman’s CR2/CD21 (C-Term) Rabbit Monoclonal Antibody can be used for immunohistochemistry (IHC) and Western blot (WB) applications.