Syntaxin-1A Rabbit Monoclonal Antibody

Syntaxin-1A is a type II integral membrane protein and member of the SNARE complex that has a major role in neuronal exocytosis.{55160,60177} It is composed of a cytoplasmic N-terminal regulatory domain, a coiled-coil SNARE domain that mediates protein-protein interactions, and a C-terminal transmembrane tail that is required for membrane localization.{60170,60171} Syntaxin-1A is located primarily on neuronal plasma membranes and associates with synaptosomal-associated protein 25 (SNAP-25), vesicle-associated membrane protein (VAMP), and the syntaxin-binding protein Munc18 to form the SNARE complex, which facilitates synaptic vesicle docking and neurotransmitter release in a calcium-dependent manner.{55160,60172} It is also found in pancreatic ? cells, where it is involved in insulin secretion, as well as in the heart.{60173,60174} STX1A SNPs have been found in patients with Asperger syndrome, attention-deficit hyperactivity disorder (ADHD), or coronary artery disease.{60174,60175,60176} Cayman's Syntaxin-1A Rabbit Monoclonal Antibody can be used for immunohistochemistry (IHC) and Western blot (WB) applications.