Cytokeratin 4 (C-Term) Rabbit Monoclonal Antibody

Cytokeratin 4 is a type II epithelial intermediate filament protein.{15723} It is composed of a central rod containing four ?-helical domains, which are important for self-assembly, and non-helical head and tail domains at the N- and C-termini, respectively. Cytokeratin 4 is expressed in mucosal stratified squamous epithelial cells, columnar luminal cells of the respiratory epithelium, and in non-stratified simple epithelial cells, with the highest expression in the esophagus and cornea.{52912} Cytokeratin 4 dimerizes with the type I epithelial intermediate filament protein cytokeratin 13, with the dimers then combining to form tetramers.{15723,52912} Mice lacking Krt4, the gene encoding cytokeratin 4, have disruptions in the epithelial integrity of the esophagus, tongue, and cornea, including basal hyperplasia, lack of cell maturation, and hyperkeratosis.{52913} Mutations in KRT4 have been associated with white sponge nevus, a disorder characterized by thickened white, spongy plaques on the oral mucosa.{52912} Cayman’s Cytokeratin 4 (C-Term) Rabbit Monoclonal Antibody can be used for immunohistochemistry (IHC) and Western blot applications.