IRF4/MUM1 (C-Term) Rabbit Monoclonal Antibody

Interferon regulatory factor 4 (IRF4), also known as multiple myeloma oncogene 1 (MUM1), is a transcription factor and member of the IRF family with roles in lymphocyte activation and the generation of immunoglobulin-secreting (Ig-secreting) plasma cells.{60143,60144} It is composed of an N-terminal DNA binding domain, a linker domain, an interferon activation domain, and a C-terminal autoinhibitory region.{60145} IRF4 is primarily expressed in plasma cells and activated T cells but is also expressed in the heart, kidney, liver, and brain.{60144,60145} Unlike other IRF transcription factors, IRF4 is not IFN-responsive and is activated by induction of the NF-?B pathway by various activators of lymphocyte activation and differentiation, such as LPS, concanavalin A (Item No. 14951), bacterial toxins, IL-4, and antigen receptor engagement.{60144} Irf4-/- mice lack Ig-secreting plasma cells, as well as exhibit defective T helper cell differentiation and decreased survival in a model of bacterial CpG-induced septic shock.{60146} IRF4 expression is associated with poor prognosis in patients with B cell chronic lymphocytic leukemia/small lymphocytic lymphoma (B-CLL/SLL).{60147} Cayman’s IRF4/MUM1 (C-Term) Rabbit Monoclonal Antibody can be used for immunohistochemistry (IHC) and Western blot (WB) applications.