Stathmin 1 (C-Term) Rabbit Monoclonal Antibody

Stathmin 1 is a microtubule-destabilizing phosphoprotein and the founding member of the stathmin family of proteins.{54622,54623} It is composed of a stathmin-like domain (SLD) that contains an N-terminal domain, a proline-rich domain, and two tubulin-binding repeats, which each bind one tubulin ?? heterodimer.{54623} Stathmin 1 also contains several phosphorylation sites which, when phosphorylated, negatively regulate its interaction with tubulin. It is ubiquitously expressed, with high levels in the nervous system, and localizes to the cytoplasm. Stathmin 1 binds to tubulin in a phosphorylation-dependent manner and regulates microtubule dynamics by promoting destabilization or preventing polymerization.{54623,54624} Stathmin 1 is inactivated prior to mitosis and reactivated by dephosphorylation near the end of mitosis.{54624} STMN1, the gene encoding stathmin, is overexpressed in a variety of cancers and is associated with metastasis and poor prognosis.{54622,54625} Cayman’s Stathmin (C-Term) Rabbit Monoclonal Antibody can be used for immunohistochemistry (IHC) and Western blot (WB) applications.