Surfactant Protein A (C-Term) Rabbit Monoclonal Antibody

Surfactant protein A (SP-A) is a hydrophilic surfactant protein and member of the collectin family with roles in microbial and apoptotic cell phagocytosis, as well as the regulation of cytokine expression.{58204,58205,58206,58207} It is composed of an N-terminal cysteine-rich domain that facilitates crosslinking of SP-A monomers, a collagen-like domain that induces multimerization, and a C-terminal carbohydrate recognition domain (CRD) for pathogen recognition. SP-A is expressed primarily in pulmonary surfactant but is also expressed in the brain, kidney, and female reproductive tract.{58207} It functions as an octadecamer that binds bacterial, fungal, and viral pathogens to enhance opsonized phagocytosis. SP-A interacts with toll-like receptors to modulate the production of various cytokines and inflammatory mediators in response to infection.{58204,58205,58206,58207} Serum levels of SP-A are associated with early relapse or exacerbation in patients with chronic obstructive pulmonary disease (COPD).{58207} Cayman’s Surfactant Protein A (C-Term) Rabbit Monoclonal Antibody can be used for immunohistochemistry (IHC) and Western blot (WB) applications.