CD19 (C-Term) Rabbit Monoclonal Antibody

CD19 is a type I transmembrane protein and member of the immunoglobulin superfamily that functions as a B cell receptor (BCR) co-receptor.{57380,57381} It is composed of an extracellular N-terminal domain containing two C2-type immunoglobulin-like (Ig-like) domains and several glycosylation sites, a transmembrane domain, and a C-terminal cytoplasmic domain containing nine tyrosine residues, which are subject to phosphorylation and mediate intracellular signaling. It is expressed on the surface of, and used as a marker for, B cells, and its expression increases during B cell maturation but decreases upon plasma cell differentiation.{57380,57381,57382} CD19 has important roles in B cell proliferation, differentiation, and survival.{57380} It associates with CD21, also known as complement receptor 2 (CR2), as well as CD82 and Leu-13, forming a multimeric complex that enhances BCR signaling.{57380,57381} CD19 functions as an adaptor protein, recruiting various cytoplasmic signaling proteins to the cell membrane that activate numerous intracellular signaling pathways, including PI3K, MAPK, and NF-?B.{57380,57381,57383} CD19 protein levels are increased in tumor cells isolated from patients with a variety of cancers of B cell origin, including chronic myelocytic leukemia and B cell lymphomas, and decreased in B cells isolated from patients with systemic lupus erythematosus (SLE).{57384,57385,57382,57381,57380} Cayman’s CD19 (C-Term) Rabbit Monoclonal Antibody can be used for immunohistochemistry (IHC) and Western blot (WB) applications.