hCG Rabbit Monoclonal Antibody

Human chorionic gonadotropin (hCG) is glycoprotein hormone secreted during pregnancy that has important roles in the maintenance of pregnancy.{52901,52902} It exists as a heterodimer that is composed of two subunits, hCG? and hCG?, that are subject to glycosylation, generating a variety of glycosylated hCG variants that have distinct biological functions.{52903,52904} The expression of genes encoding hCG? and hCG? are regulated by a variety of hormones, growth factors, and cytokines.{52904} It is secreted by placental trophoblasts during early pregnancy and serum hCG levels peak from gestational weeks 7 to 10.{52901} hCG has numerous roles in pregnancy, including stimulating production of progesterone from the corpus luteum and promoting angiogenesis of uterine vasculature and the growth of fetal organs.{52905} Urinary hCG levels have been commonly used in the determination of pregnancy.{52901} Increased serum, urinary, or tumor levels of hCG? have been found in patients with a variety of cancers, including bladder, lung, cervical, or ovarian cancer, and are associated with poor prognosis.{52906} Cayman's hCG Rabbit Monoclonal Antibody can be used for ELISA, immunohistochemistry (IHC), and Western blot (WB) applications. This antibody recognizes the hCG? subunit in both the monomeric and hCG?? heterodimeric forms.