Cytokeratin 14 (C-Term) Rabbit Monoclonal Antibody

Cytokeratin 14 (CK-14) is a type I acidic epithelial intermediate filament protein.{59574} It is composed of a central rod containing four ?-helical domains, which are important for self-assembly, and non-helical head and tail domains at the N- and C-termini, respectively.{59575,59576} CK-14 is expressed in stratified squamous epithelial cells, keratinocytes, and myoepithelial cells in the basal layer of the epidermis and is an integral component of the epithelial cell cytoskeleton.{59574,59577,59578} It dimerizes with the type II basic epithelial intermediate filament protein CK-5 via heptad repeats in the central rod domain to form a network of filament bundles throughout the cytoplasm.{59575,59576} Increased tumor levels of CK-14 have been found in patients with squamous cell carcinomas of the bladder, lung, or cervix.{59579} Mutations in the gene encoding CK-14 have been found in patients with epidermolysis bullosa simplex (EBS), a disorder characterized by skin blistering.{58059} Cayman's Cytokeratin 14 (C-Term) Rabbit Monoclonal Antibody can be used for immunohistochemistry (IHC) and Western blot (WB) applications.