PSMA (C-Term) Rabbit Monoclonal Antibody

Prostate-specific membrane antigen (PSMA) is a type II membrane glycoprotein and a glutamate-preferring carboxypeptidase with roles in folic acid utilization and metabolism encoded by FOLH1 in humans.{60113,60116} It is composed of a short intracellular domain, a transmembrane domain, and a large extracellular region that contains enzymatic domains.{60113,60114} PSMA is expressed in prostate epithelial cells and is highly overexpressed in prostate carcinomas. PSMA is also expressed in the central nervous system, where it metabolizes N-acetyl-aspartyl-glutamate, and in the proximal small intestine, where it functions as a carboxypeptidase and a folate hydrolase, as well as in the neovasculature of various renal, colon, and breast carcinomas.{60116,60115} Expression of FOLH1 increases under androgen deprivation conditions in vitro and in vivo and positively correlates with cancer aggressiveness in patients with prostate cancer.{60113} PSMA positron emission tomography (PET) imaging is commonly used in the diagnosis and staging of prostate cancer, as well as to assess therapeutic response.{60114} Cayman’s PSMA (C-Term) Rabbit Monoclonal Antibody can be used for immunohistochemistry (IHC) and Western blot (WB) applications.