CEA Rabbit Monoclonal Antibody

Carcinoembryonic antigen (CEA) is a glycoprotein and member of the immunoglobulin (Ig) superfamily with a role in cell adhesion.{54660,12007,54661} It is composed of an N-terminal Ig variable domain-like (IgV-like) domain, six Ig constant 2-like (IgC2-like) domains, and a glycosylphosphatidylinositol (GPI) anchor that is attached to the cell membrane.{54660} CEA is expressed during fetal development but is absent by birth and is not present in adults.{54661} However, CEA is expressed by human colon carcinomas where it functions as a ligand for E-selectin and L-selectin that is essential to cancer metastasis. Levels of CEA are positively correlated with risk of recurrence and death in patients with non-small cell lung cancer (NSCLC). Cayman’s CEA Rabbit Monoclonal Antibody can be used for ELISA, immunohistochemistry (IHC), and Western blot (WB) applications.