Calretinin (N-Term) Rabbit Monoclonal Antibody

Calretinin is a calcium-binding protein and member of the large EF-hand protein family that is encoded by CALB2 in humans.{59515} It is composed of six EF-hand domains, each of which contains two ?-helices oriented perpendicular to each other around a calcium-binding domain. Calretinin is expressed in specific neuronal populations, including granule cells of the cerebellum, auditory neurons, and retinal neurons, and is localized to the cytosol where it has a role in the modulation of neuronal excitability. It is also expressed under pathological conditions, particularly in epithelial mesothelioma cells and colon adenocarcinomas. Calb2-/- mice exhibit impaired induction of long-term potentiation following tetanic hippocampal stimulation. Levels of calretinin are increased in the dorsomedial and ventromedial hypothalamic nuclei in aged rats.{59516} Cayman's Calretinin (N-Term) Rabbit Monoclonal Antibody can be used for immunohistochemistry (IHC) and Western blot (WB) applications.