a-Tubulin K40Ac Rabbit Monoclonal Antibody

?-Tubulin is a cytoskeletal protein and constituent of microtubules, a cytoskeletal assembly that has roles in a variety of cellular processes, including cell motility, division, differentiation, and intracellular transport.{57121} ?-Tubulin is highly conserved in eukaryotes and expressed in a cell- and isotype-specific manner.{57122} There are eight human ?-tubulin isotypes that consist of an N-terminal domain, which binds GTP and is required for microtubule self-assembly, and a variable C-terminal tail, which contains interaction sites for microtubule-associated proteins (MAPs) and is subject to a variety of post-translational modifications that regulate microtubule function and stability.{57123,57124,57121,57125} ?-Tubulin can be acetylated at a variety of sites, including on the luminal side of microtubules at lysine 40 (K40Ac), by ?-tubulin N-acetyltransferase 1 (?-TAT) and deacetylated primarily by histone deacetylase 6 (HDAC6).{52895,52896} ?-Tubulin K40Ac is a marker of stable microtubules that recruits dynein and kinesin-1 to microtubules. It is also involved in regulating microtubule architecture as well as immune and viral responses.{52895,52897,52896} The levels of ?-tubulin acetylation are decreased in a variety of neurological disorders, increased in various cancers, and dysregulated in immune disorders.{52896} Cayman’s ?-Tubulin K40Ac Rabbit Monoclonal Antibody can be used for immunocytochemistry (ICC) and Western blot (WB) applications.