PLAP (N-Term) Rabbit Monoclonal Antibody

Placental alkaline phosphatase (PLAP) is the placenta-specific isoenzyme of AP encoded by the ALPP gene in humans.{59555,59556} It exists as a homodimer where each monomer is composed of an N-terminal ?-helix and a crown domain that stabilize PLAP homodimers, a Zn2+- and Mg2+-containing active site with a catalytic serine residue, and a non-catalytic metal-binding site occupied by Ca2+.{59558,59557} PLAP is predominately expressed by syncytiotrophoblasts in the placenta and is tethered to the plasma membrane by a glycosylphosphatidylinositol (GPI) anchor.{59557,59558} It is also present at low levels in the cervix, ovaries, and type I pneumocytes, as well as in the serum.{59555,59558} Increased PLAP activity has been found in tumor tissue and cerebrospinal fluid (CSF) isolated from patients with intracranial germ cell tumors.{59559} Cayman's PLAP (N-Term) Rabbit Monoclonal Antibody can be used for immunohistochemistry (IHC) and Western blot (WB) applications.