eIF2a (Phospho-Ser51) Rabbit Monoclonal Antibody

eIF2? is the ? subunit of eukaryotic inhibition factor 2, which also includes eIF2? and eIF2? subunits and is involved in the initiation of translation.{59683} eIF2? is composed of a globular N-terminal domain, which contains an S1 domain and an ?-helical domain, and a globular C-terminal domain.{59684} eIF2? can be phosphorylated at serine 51 by the eIF2? kinases HRI/EIF2AK1, PKR/EIF2AK2, PERK/EIF2AK3, and GCN2/EIF2AK4 following various cell and ER stressors, viral invasion, or nutrient deprivation, among other factors.{59685,59686,59687} Phosphorylation of eIF2? at serine 51 promotes the interaction between eIF2? and the guanine nucleotide exchange factor eIF2B, which inhibits eIF2B activity and prevents the initiation of translation, reducing global protein synthesis in the cell.{59683} The transcription of specific factors involved in the integrated stress response (ISR), such as ATF4, is upregulated by eIF2? phosphorylation.{59685} Dephosphorylation of eIF2? by the protein phosphatase 1 (PP1) complex, which includes GADD34 and CReP, terminates the ISR and returns protein synthesis back to basal levels. Cayman’s eIF2? (Phospho-Ser51) Rabbit Monoclonal Antibody can be used for immunohistochemistry (IHC) and Western blot (WB) applications.