PSD-95 (N-Term) Rabbit Monoclonal Antibody (Clone RM288)

Postsynaptic density protein-95 (PSD-95) is a scaffold protein and member of the membrane-associated guanylate kinase (MAGUK) family encoded by the DLG4 gene in humans.{59679,59680} It is composed of three N-terminal PDZ domains that facilitate protein-protein interactions and are subject to palmitoylation, which regulates its membrane localization, a Src homology domain that interacts with the tyrosine kinases Src, Lyn, and Yes, and a C-terminal catalytically inactive guanylate kinase domain.{59679} PSD-95 is expressed in excitatory synapses and localizes to the postsynaptic density, a network of proteins that facilitates the stabilization and trafficking of receptors and ion channels to the postsynaptic membrane.{59679,59681} PSD-95 interacts with the transmembrane AMPA receptor-associated protein stargazin, as well as the NR2 subunit of the NMDA receptor, regulating glutamatergic signaling, synaptic plasticity, and neurodevelopment.{59679,59682} DLG4 mutations have been found in patients with schizophrenia or autism.{59679} Cayman's PSD-95 (N-Term) Rabbit Monoclonal Antibody (Clone RM288) can be used for immunohistochemistry (IHC) and Western blot (WB) applications.