Integrin B1/CD29 Rabbit Monoclonal Antibody

Integrins are cell adhesion receptors that mediate the attachment of cells to the extracellular matrix (ECM) and facilitate cell-cell interactions.{59572} The integrin family contains 18 ? subunits and eight ? subunits that form 24 different heterodimers grouped into familial subgroups based on subunit composition and/or their ligand binding properties. Integrin ?1, also known as CD29, is an integrin subunit that heterodimerizes with ? integrin subunits, forming 12 different ?-? integrin heterodimers that function as receptors for a variety of ECM proteins, including collagens, fibronectins, and laminins, and mediate outside-in and inside-out signaling cascades that regulate numerous cellular processes, including proliferation, adhesion, survival, migration, and organogenesis.{59652} Integrin ?1 is expressed in most tissues, with high levels found in epidermal stem cells.{59653,59572} Increased tumor levels of integrin ?1 have been found in patients with lung or breast cancer and are associated with decreased overall survival.{59654} Cayman's Integrin ?1/CD29 Rabbit Monoclonal Antibody can be used for immunohistochemistry (IHC) and Western blot (WB) applications.