Cytokeratin 7 (C-Term) Rabbit Monoclonal Antibody

Cytokeratin 7 (CK7) is an intermediate filament protein and a member of the cytokeratin protein family.{59484,59485} It is a type II neutral-basic cytokeratin expressed in ductal, glandular, and transitional epithelial tissues, as well as endothelial cells, but not stratified squamous epithelia, and is localized to the cytoplasm.{59485,59486} CK7 is found in various tumors, including ductal, lobular, and mucinous carcinomas, as well as ovarian, but not colorectal, adenocarcinomas, malignant mesotheliomas, and transitional cell carcinomas.{59486} It is also found in chromophobe renal cell carcinomas but not oncocytoma and conventional carcinomas and has been used as a biomarker for differentiation of tumor origin.{59487} Hepatocyte expression of CK7 is positively correlated with fibrosis stage in patients with hepatitis B and hepatitis C.{59488} Cayman’s Cytokeratin 7 (C-Term) Rabbit Monoclonal Antibody can be used for immunohistochemistry (IHC) and Western blot (WB) applications.