Cytokeratin 18 Rabbit Monoclonal Antibody

Cytokeratin 18 (CK18) is an intermediate filament protein and a member of the cytokeratin protein family.{59484} It is a type I acidic cytokeratin expressed in epithelial tissues, including those found in liver, lung, kidney, pancreas, and the gastrointestinal tract, and is localized in the cytoplasm and perinuclear region. CK18 is co-expressed with the type II neutral-basic cytokeratin CK8, with which it forms intermediate filaments essential to cytoplasmic structure. During apoptosis, CK18 is cleaved by caspases and released from the cell, and is commonly used as a marker of epithelial cell death.{59639} Plasma levels of CK18 positively correlate with the magnitude of hepatocyte apoptosis in patients with non-alcoholic fatty liver disease (NAFLD) and are independently predictive of non-alcoholic steatohepatitis (NASH).{59640} Serum levels of CK18 are elevated in patients with cardiometabolic disorders, including diabetes and hypertension, in an NAFLD-independent manner.{59639} CK18 tumor expression positively correlates with poorly differentiated oral squamous cell carcinoma (OSCC) tumors and poor prognosis.{59641} Cayman’s Cytokeratin 18 Rabbit Monoclonal Antibody can be used for immunohistochemistry (IHC) and Western blot (WB) applications.