JAM-A (N-Term) Rabbit Monoclonal Antibody

Junctional adhesion molecule A (JAM-A), known previously as JAM-1, is a type I transmembrane protein and member of the immunoglobulin (Ig) superfamily that regulates epithelial and endothelial barrier and tight junction formation.{59625,59626,59627} It is comprised of an N-terminal extracellular domain containing two Ig-like domains that mediate cell-cell interactions, a single transmembrane domain, and a cytoplasmic tail containing a PDZ binding motif that interacts with numerous cytoplasmic scaffold proteins and intracellular signaling molecules.{59625,59626} JAM-A exists as a monomer or homodimer, is primarily expressed by epithelial cells, endothelial cells, and leukocytes, and localizes to the cell surface.{59625} It associates via cis- or trans-interactions with a variety of cell surface proteins, including the additional JAM family members JAM-B and JAM-C, which are also expressed by epithelial cells, endothelial cells, and leukocytes, as well as integrins expressed by leukocytes, such as ?L?2, ?M?2, and ?4?1, to mediate homotypic or heterotypic cell-cell adhesions that regulate tight junction assembly and transepithelial cell migration. JAM-A has additional roles in angiogenesis, hemostasis, cell cycle, and inflammation. JAM-A levels are increased in plasma cells isolated from patients with multiple myeloma and are associated with poor prognosis.{59628} Cayman's JAM-A (N-Term) Rabbit Monoclonal Antibody can be used for immunohistochemistry (IHC) and Western blot (WB) applications.