mTOR Rabbit Monoclonal Antibody

Mammalian target of rapamycin (mTOR) is a serine/threonine kinase and member of the PI3K-related kinase family with roles in the regulation of cell growth and metabolism.{59620,59621} It is comprised of N-terminal tandemly repeated HEAT motifs that facilitate protein-protein interactions, a FRAP, ATM, and TRRAP (FAT) domain, an FKBP12-rapamycin binding (FRB) domain, a catalytic kinase domain, an autoinhibitory/repressor domain, and a FAT carboxy-terminal (FATC) domain that is essential to kinase activity.{59621} mTOR is ubiquitously expressed in the cytosol and is the catalytic subunit of mTOR complex 1 (mTORC1) and mTORC2, which have roles in aging, autophagy, stem cell and immune function, cellular senescence, and macromolecule biogenesis, and cell survival, cytoskeletal organization, and metabolism, respectively.{59621,59622} It is a component of the PI3K/AKT/mTOR signaling pathway that acts as a junction point both upstream and downstream of AKT.{59623} Dysregulation of the mTOR signaling pathway is associated with various pathologies, including cancer, rheumatoid arthritis, epilepsy, neurodegenerative diseases, and diabetes.{59623,59624,59621} Cayman’s mTOR Rabbit Monoclonal Antibody can be used for immunohistochemistry (IHC) and Western blot (WB) applications.